Feb 23 2020

Researchers once again seek answers from the soil.

Published by at 12:18 pm under Antibiotics,probiotic supplements

Researchers once again seek answers from the soil.
A new group of antibiotics, found in the soil, proves promising against drug resistant infections. 1*

As we have covered many times before, the race to find new antibiotics that can fight bacteria is one that scientists and researchers are desperately trying to win. The overuse of antibiotics has continued to be a growing concern, in both humans and livestock, as many antibiotics have become ineffective. Globally, we are faced with many bacterial infections becoming untreatable and this crisis will only grow direr as bacteria morph and become more resilient. As with C. Diff, and many strains of staphylococcus, despite several rounds of antibiotic therapy, these bacteria prevail, resulting in the death of those infected. (1,2)*

Researchers are finding that to address the global antibiotic-resistant drug crisis, they must seek answers outside the norm and discover compounds with unique mechanisms of action. They are constantly searching for new antibiotics and the soil is their ground zero. As Body Biotics™ Bio-Identical SBO Probiotics Consortia™ was formulated from nature’s own soil-borne microorganisms, the answer to so many things can be found there. And, it is there that a new antibiotic has been discovered.1*

A team with the David Braley Centre for Antibiotic Discovery within the Michael G. DeGroote Institute for Infectious Disease Research at McMaster and led by professor Gerry Wright and was funded by the Canadian Institutes of Health Research and the Ontario Research Fund discovered a new group of antibiotics that take a novel approach to attack bacteria. Corbomycin and compstatin are promising clinical candidates in the fight against antimicrobial resistance in that they have “…a never-before-seen way to kill bacteria, which is achieved by blocking the function of the bacterial cell wall. The discovery comes from a family of antibiotics called glycopeptides that are produced by soil bacteria….”(1,2)*

The research, which was published in Nature, shows promise in a way that hadn’t yet been realized. “…”Bacteria have a wall around the outside of their cells that gives them shape and is a source of strength,” said study first author Beth Culp, a Ph.D. candidate in biochemistry and biomedical sciences at McMaster…”(1,2)*

The antibiotics that these researchers found do the opposite of what antibiotics like penicillin do, which is kill bacteria by preventing the building of the bacterial cell wall. These new antibiotics do the opposite in that they prevent the wall from being broken down, which is critical for the cells to divide, expand and multiply. “…”If you completely block the breakdown of the wall, it is like it is trapped in a prison, and can’t expand or grow.”…”(1,2)*

Researchers studied “…the family tree of known members of the glycopeptides…” and studied those genes known to lack resistance mechanisms, “…with the idea they might be an antibiotic demonstrating a different way to attack bacteria…”(1,2)*

Culp and the researchers hypothesized that “…” if the genes that made these antibiotics were different, maybe the way they killed the bacteria was also different,”…” They surmised that this approach can be applied to other antibiotics, which can lead to the discovery of other new ones with different mechanisms of action. “…”We found one completely new antibiotic in this study, but since then, we’ve found a few others in the same family that has this same new mechanism.”…”(1,2)*

This is great news and there is a lot of attention being given to this matter by the Center for Disease Control in the search for new antibiotics. “The CDC’s response to antibiotic resistance implements activities outlined in the U.S. National Action Plan for Combating Antibiotic-Resistant Bacteria. In the fiscal year 2016, Congress appropriated an unprecedented $160 million of new investments for CDC to fight antibiotic resistance. With these investments, CDC implemented the AR Solutions Initiative to work toward meeting the national goals. This appropriation increased to $170 million in the fiscal year 2020.”3*

 The first line of defense comes from the soil by ingesting the friendly soil born bacteria that fortify the gut, building a strong immune system. By keeping our defenses strong and using soil born bacteria such as those found in Body Biotics™ Bio-Identical SBO Probiotics Consortia™, we maintain our gut health so that when exposed to dangerous bacteria, we are better armed to fight them off. By using them sparingly, and only when necessary, antibiotics can prevent the spread of infection and keep it from getting worse. As bacteria and various infections and their treatments evolve, researchers will continue to look to the soil and to innovative solutions to develop new treatments, preventions, and ultimately cures.*  

Healthiest wishes,

Kelli

 www.bodybiotics.com

Resources:

  1. https://www.sciencedaily.com/releases/2020/02/200212131523.htm
  2. https://www.nature.com/articles/s41586-020-1990-9?amp%3Bcode=d61c8e22-32be-4b99-a000-a6d9762e87e9
  3. https://www.cdc.gov/drugresistance/solutions-initiative/index.html


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