Jun 02 2013

Probiotic Bacteria and Mechanisms of Action

Published by at 10:19 am under probiotic supplements

Probiotic organisms are thought to have four basic mechanisms of action.


1. Through fermentation, they secrete helpful compounds that either nourish other cells
(such as those in the colon or liver), alter the colonic environment, or serve as signals to
communicate with the immune system. These compounds may include vitamins,
antioxidants, enzymes, bioactive peptides, organic acids, and polysaccharides
[Bravo, 1998, Tieking, et al.,  2003, Zvauya, et al., 1997, Seppo, et al., 2003,
Calderon, et al., 2003, Mensah, et al., 1995, and Olsen, et al., 1995].

2. They inhibit the growth of organisms that are harmful to humans by either secreting
antimicrobial substances, or by blocking the ability of the harmful organisms to adhere
to or puncture the gut wall [Rolfe, 2002];

3. They prevent the build-up of waste materials and toxic compounds in the colon by
either blocking their formation or by breaking toxins and waste materials down into
harmless  molecules that can be easily eliminated [Rolfe, 2002].

4. They exhibit strong antioxidant activities, which include the ability to scavenge
reactive oxygen species, chelate metal ions, such as iron and copper, inhibit the
formation of the enzymes that create reactive oxygen species, and reduce oxidants
[Lin, et al., 1999].

 The technical truth of the matter.  For more on this go to our Home Page and click on

The Executive Summary Link near the top of the page under the first paragraph.




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